Representation of EHR data for predictive modeling: a comparison between UMLS and other terminologies

Mr. Amol Dattatray Dhaygude Dr. Suman Kumar Swarnkar + 4 lainnya

14 September 2023

Predictive modeling of disease progression in chronic conditions is a crucial task in healthcare, as it enables early identification and personalized intervention for patients at risk of adverse outcomes. In recent times, there has been a notable advancement in the field of machine learning techniques, which has demonstrated considerable potential in accurately forecasting the evolution of diseases. This development has proven to be highly beneficial for healthcare professionals, as it equips them with vital insights that can significantly enhance the management of patients. This research paper provides a thorough examination and comparative evaluation of different machine learning algorithms in the context of forecasting the course of diseases in chronic situations. We explore the use of diverse datasets containing longitudinal patient records, clinical variables, and disease-specific markers to train and evaluate predictive models. The study also investigates the impact of feature selection and data preprocessing techniques on the model's performance. Moreover, we assess the generalizability and robustness of the models across different chronic diseases to determine their potential for broader clinical applications. The results demonstrate that machine learning models can effectively predict disease progression, with certain algorithms outperforming others in specific scenarios. The research findings presented in this study offer significant contributions to the understanding and implementation of machine learning techniques for predicting disease development. The aforementioned realizations have the potential to be of substantial assistance to medical professionals in terms of making well-informed decisions, which will ultimately lead to better outcomes for patients.

Zhenzhu Li Ying Weng Boding Wang + 2 lainnya

1 Januari 2023

In the era of big data, text-based medical data, such as electronic health records (EHR) and electronic medical records (EMR), are growing rapidly. EHR and EMR are collected from patients to record their basic information, lab tests, vital signs, clinical notes, and reports. EHR and EMR contain the helpful information to assist oncologists in computer-aided diagnosis and decision making. However, it is time consuming for doctors to extract the valuable information they need and analyze the information from the EHR and EMR data. Recently, more and more research works have applied natural language processing (NLP) techniques, i.e., rule-based, machine learning-based, and deep learning-based techniques, on the EHR and EMR data for computer-aided diagnosis in oncology. The objective of this review is to narratively review the recent progress in the area of NLP applications for computer-aided diagnosis in oncology. Moreover, we intend to reduce the research gap between artificial intelligence (AI) experts and clinical specialists to design better NLP applications. We originally identified 295 articles from the three electronic databases: PubMed, Google Scholar, and ACL Anthology; then, we removed the duplicated papers and manually screened the irrelevant papers based on the content of the abstract; finally, we included a total of 23 articles after the screening process of the literature review. Furthermore, we provided an in-depth analysis and categorized these studies into seven cancer types: breast cancer, lung cancer, liver cancer, prostate cancer, pancreatic cancer, colorectal cancer, and brain tumors. Additionally, we identified the current limitations of NLP applications on supporting the clinical practices and we suggest some promising future research directions in this paper.

Muchao Ye Jiaqi Wang Xiaochen Wang + 8 lainnya

2 Februari 2024

The development of electronic health records (EHR) systems has enabled the collection of a vast amount of digitized patient data. However, utilizing EHR data for predictive modeling presents several challenges due to its unique characteristics. With the advancements in machine learning techniques, deep learning has demonstrated its superiority in various applications, including healthcare. This survey systematically reviews recent advances in deep learning-based predictive models using EHR data. Specifically, we introduce the background of EHR data and provide a mathematical definition of the predictive modeling task. We then categorize and summarize predictive deep models from multiple perspectives. Furthermore, we present benchmarks and toolkits relevant to predictive modeling in healthcare. Finally, we conclude this survey by discussing open challenges and suggesting promising directions for future research.

M. Haendel Peter N. Robinson

1 Agustus 2020

Summary Objectives: To select, present, and summarize the most relevant papers published in 2018 and 2019 in the field of Ontologies and Knowledge Representation, with a particular focus on the intersection between Ontologies and Machine Learning. Methods: A comprehensive review of the medical informatics literature was performed to select the most interesting papers published in 2018 and 2019 and that document the utility of ontologies for computational analysis, including machine learning. Results: Fifteen articles were selected for inclusion in this survey paper. The chosen articles belong to three major themes: (i) the identification of phenotypic abnormalities in electronic health record (EHR) data using the Human Phenotype Ontology ; (ii) word and node embedding algorithms to supplement natural language processing (NLP) of EHRs and other medical texts; and (iii) hybrid ontology and NLP-based approaches to extracting structured and unstructured components of EHRs. Conclusion: Unprecedented amounts of clinically relevant data are now available for clinical and research use. Machine learning is increasingly being applied to these data sources for predictive analytics, precision medicine, and differential diagnosis. Ontologies have become an essential component of software pipelines designed to extract, code, and analyze clinical information by machine learning algorithms. The intersection of machine learning and semantics is proving to be an innovative space in clinical research.

Peng Li Haitao Cheng Z. Xie + 4 lainnya

12 Agustus 2022

The deep learning methods for various disease prediction tasks have become very effective and even surpass human experts. However, the lack of interpretability and medical expertise limits its clinical application. This paper combines knowledge representation learning and deep learning methods, and a disease prediction model is constructed. The model initially constructs the relationship graph between the physical indicator and the test value based on the normal range of human physical examination index. And the human physical examination index for testing value by knowledge representation learning model is encoded. Then, the patient physical examination data is represented as a vector and input into a deep learning model built with self-attention mechanism and convolutional neural network to implement disease prediction. The experimental results show that the model which is used in diabetes prediction yields an accuracy of 97.18% and the recall of 87.55%, which outperforms other machine learning methods (e.g., lasso, ridge, support vector machine, random forest, and XGBoost). Compared with the best performing random forest method, the recall is increased by 5.34%, respectively. Therefore, it can be concluded that the application of medical knowledge into deep learning through knowledge representation learning can be used in diabetes prediction for the purpose of early detection and assisting diagnosis.