Recent Advances in Predictive Modeling with Electronic Health Records

Joseph C. Wu L. Xing James Zou + 1 lainnya

4 Juli 2022

In the past decade, the application of machine learning (ML) to healthcare has helped drive the automation of physician tasks as well as enhancements in clinical capabilities and access to care. This progress has emphasized that, from model development to model deployment, data play central roles. In this Review, we provide a data-centric view of the innovations and challenges that are defining ML for healthcare. We discuss deep generative models and federated learning as strategies to augment datasets for improved model performance, as well as the use of the more recent transformer models for handling larger datasets and enhancing the modelling of clinical text. We also discuss data-focused problems in the deployment of ML, emphasizing the need to efficiently deliver data to ML models for timely clinical predictions and to account for natural data shifts that can deteriorate model performance. This Review discusses the use of deep generative models, federated learning and transformer models to address challenges in the deployment of machine learning for healthcare.

Azhar Al Salam Hussein Abdel-Jaber Lamya Hidaytallah + 2 lainnya

21 Februari 2022

Deep learning uses artificial neural networks to recognize patterns and learn from them to make decisions. Deep learning is a type of machine learning that uses artificial neural networks to mimic the human brain. It uses machine learning methods such as supervised, semi-supervised, or unsupervised learning strategies to learn automatically in deep architectures and has gained much popularity due to its superior ability to learn from huge amounts of data. It was found that deep learning approaches can be used for big data analysis successfully. Applications include virtual assistants such as Alexa and Siri, facial recognition, personalization, natural language processing, autonomous cars, automatic handwriting generation, news aggregation, the colorization of black and white images, the addition of sound to silent films, pixel restoration, and deep dreaming. As a review, this paper aims to categorically cover several widely used deep learning algorithms along with their architectures and their practical applications: backpropagation, autoencoders, variational autoencoders, restricted Boltzmann machines, deep belief networks, convolutional neural networks, recurrent neural networks, generative adversarial networks, capsnets, transformer, embeddings from language models, bidirectional encoder representations from transformers, and attention in natural language processing. In addition, challenges of deep learning are also presented in this paper, such as AutoML-Zero, neural architecture search, evolutionary deep learning, and others. The pros and cons of these algorithms and their applications in healthcare are explored, alongside the future direction of this domain. This paper presents a review and a checkpoint to systemize the popular algorithms and to encourage further innovation regarding their applications. For new researchers in the field of deep learning, this review can help them to obtain many details about the advantages, disadvantages, applications, and working mechanisms of a number of deep learning algorithms. In addition, we introduce detailed information on how to apply several deep learning algorithms in healthcare, such as in relation to the COVID-19 pandemic. By presenting many challenges of deep learning in one section, we hope to increase awareness of these challenges, and how they can be dealt with. This could also motivate researchers to find solutions for these challenges.

Naseebia Khan Gopal Kumar Thakur Shahnawaz Khan + 2 lainnya

1 Mei 2024

In addition to enhancing diagnostic accuracy, deep learning techniques offer the potential to streamline workflows, reduce interpretation time, and ultimately improve patient outcomes. The scalability and adaptability of deep learning algorithms enable their deployment across diverse clinical settings, ranging from radiology departments to point-of-care facilities. Furthermore, ongoing research efforts focus on addressing the challenges of data heterogeneity, model interpretability, and regulatory compliance, paving the way for seamless integration of deep learning solutions into routine clinical practice. As the field continues to evolve, collaborations between clinicians, data scientists, and industry stakeholders will be paramount in harnessing the full potential of deep learning for advancing medical image analysis and diagnosis. Furthermore, the integration of deep learning algorithms with other technologies, including natural language processing and computer vision, may foster multimodal medical data analysis and clinical decision support systems to improve patient care. The future of deep learning in medical image analysis and diagnosis is promising. With each success and advancement, this technology is getting closer to being leveraged for medical purposes. Beyond medical image analysis, patient care pathways like multimodal imaging, imaging genomics, and intelligent operating rooms or intensive care units can benefit from deep learning models.

Firat Tiryaki Yujia Zhou Degui Zhi + 4 lainnya

15 September 2020

OBJECTIVE Predictive disease modeling using electronic health record data is a growing field. Although clinical data in their raw form can be used directly for predictive modeling, it is a common practice to map data to standard terminologies to facilitate data aggregation and reuse. There is, however, a lack of systematic investigation of how different representations could affect the performance of predictive models, especially in the context of machine learning and deep learning. MATERIALS AND METHODS We projected the input diagnoses data in the Cerner HealthFacts database to Unified Medical Language System (UMLS) and 5 other terminologies, including CCS, CCSR, ICD-9, ICD-10, and PheWAS, and evaluated the prediction performances of these terminologies on 2 different tasks: the risk prediction of heart failure in diabetes patients and the risk prediction of pancreatic cancer. Two popular models were evaluated: logistic regression and a recurrent neural network. RESULTS For logistic regression, using UMLS delivered the optimal area under the receiver operating characteristics (AUROC) results in both dengue hemorrhagic fever (81.15%) and pancreatic cancer (80.53%) tasks. For recurrent neural network, UMLS worked best for pancreatic cancer prediction (AUROC 82.24%), second only (AUROC 85.55%) to PheWAS (AUROC 85.87%) for dengue hemorrhagic fever prediction. DISCUSSION/CONCLUSION In our experiments, terminologies with larger vocabularies and finer-grained representations were associated with better prediction performances. In particular, UMLS is consistently 1 of the best-performing ones. We believe that our work may help to inform better designs of predictive models, although further investigation is warranted.

Iqbal H. Sarker

2 Agustus 2021

Deep learning (DL), a branch of machine learning (ML) and artificial intelligence (AI) is nowadays considered as a core technology of today’s Fourth Industrial Revolution (4IR or Industry 4.0). Due to its learning capabilities from data, DL technology originated from artificial neural network (ANN), has become a hot topic in the context of computing, and is widely applied in various application areas like healthcare, visual recognition, text analytics, cybersecurity, and many more. However, building an appropriate DL model is a challenging task, due to the dynamic nature and variations in real-world problems and data. Moreover, the lack of core understanding turns DL methods into black-box machines that hamper development at the standard level. This article presents a structured and comprehensive view on DL techniques including a taxonomy considering various types of real-world tasks like supervised or unsupervised. In our taxonomy, we take into account deep networks for supervised or discriminative learning, unsupervised or generative learning as well as hybrid learning and relevant others. We also summarize real-world application areas where deep learning techniques can be used. Finally, we point out ten potential aspects for future generation DL modeling with research directions. Overall, this article aims to draw a big picture on DL modeling that can be used as a reference guide for both academia and industry professionals.